For those interested in joining our Lab, please visit the OPEN POSITIONS page for more information!
|Farshad Abdollah-Nia, Ph.D., Postdoctoral Fellow|
I am interested in understanding how bacterial cells manage the production of proteins, as well as the flux of metabolites in different growth conditions. I use mass spectrometry to quantify protein levels on a cell-wide scale in E. coli. Then I apply mathematical models that describe the dynamics of large groups of proteins. These models help us understand global resource allocation strategies in cells and enable us to predict the growth and the makeup of the cells in various environments.
Contact: firstname.lastname@example.org | LinkedIn
|Xiyu Dong, B.S., Graduate Student|
My interest is in bacterial ribosome biogenesis. Ribosome assembly is a complicated but rapid process in vivo. An in vitro ribosome reconstruction system can slow this process and provide the insights into the mechanism of ribosome assembly. I’m now working on the visualization of incomplete ribosome particles with cryo-EM. Besides, I’m also interested in identifying RNA modifications in bacteria by quantitative mass spectrometry.
|John Hammond, Ph.D., Biophysics Core Director|
I am interested in the assembly, function, and structure of viral/host ribonucleoprotein complexes. Of late, we have been studying the assembly of a nuclear export complex required for HIV-1 replication, as well as understanding the assembly of the HIV-1 virus. This work uses a variety of biochemical, biophysical and cellular biology techniques to provide a universal structural and functional view of these RNP processes.
|Joan Lee, B.S., Research Assistant|
I earned a B.S. in Biochemistry/Chemistry from the University of California, San Diego, and graduated with the highest departmental honors. During my undergraduate research, I studied the binding affinity between NFκB and transcription coactivators, such as ribosomal protein S3, and their binding affinity with various DNA. I am currently studying ribosomal intermediates in E.coli using cryo-electron tomography in the Williamson and Grotjahn Labs.
|Anna Popova, Ph.D., Staff Scientist|
I am particularly fond of rRNA modifications! All different kinds, found in bacteria, yeast, and human cells. Using modern mass spectrometry tools, I can identify and quantify relative abundance of RNA modifications in mature ribosomes and the intermediates. This quantitative approach proved to be effective in understanding modifications as part of the ribosome biogenesis process.
Contact: email@example.com | LinkedIn | ResearchGate |
|Julia Polay, Lab Administrative Coordinator|
While my own background stems from an education and career outside of the sciences, I have spent the better part of the last decade surrounded by chemists. My previous experiences have demanded acute organization, clear communication, and an eye for detail. Nothing gives me more fulfillment than supporting a team of great minds and helping them achieve results.
Contact: firstname.lastname@example.org | LinkedIn
|Lincoln Scott, Ph.D., Visiting Investigator|
I am interested in the chemo-enzymatic synthesis of isotopically labeled nucleotides and nucleotide analogs. These compounds are used in a variety of NMR and mass spectrometry based biophysical studies of RNA and RNA-protein complexes. This work has led to the formation of Cassia LLC, a company that prepares isotopically labeled primary metabolites for the biophysical research community.
Contact: Cassia, LLC | LinkedIn | ResearchGate
|Kai Sheng, B.S., Graduate Student|
I was trained as a chemical biologist during my undergraduate research, developing methodology in protein modifications and its applications in therapeutics. I also had one year working with Floyd Romesberg, exploring the exciting semi-synthetic organism. Now I turned my research interest to ribosomes, one of the most beautiful, sophisticated and meanwhile complex systems in biology. I am now using the in vitro ribosome assembly assay to screen inhibitors which are specific for the assembling process.
|Qing “Sunny” Zhao, M.S., Rotation Student|
I obtained my Master of Science Degree in Biochemistry and Molecular Biology from the University of Southern California, where I have focused on the research field of epigenetics. I am now fascinated by the studies related to the role of RNA modifications in regulating gene expression and other critical cellular processes. Currently, as a rotation student in Dr. Williamson’s laboratory, I am working on a project that aims to investigate the interactome of several RNA methyltransferases modifying E. coli ribosome 50S subunit during the ribosome assembly process.
|Poppy Chen, Research Intern|
I’m currently an undergraduate student at UCSD, majoring in Biochemistry/Chemistry. I conducted my previous undergraduate research on protein-drug conjugate that can target ovarian cancer cells. Currently, I turned my research interest to structural biology. As an intern in this lab, I’m working on projects to probe E.coli ribosome assembly in vivo.